Lincomycin Resistance Mutations in Two Regions Immediately Downstream of the −10 Region of lmr Promoter Cause Overexpression of a Putative Multidrug Efflux Pump in Bacillus subtilis Mutants

We isolated 19 lincomycin-resistant Bacillus subtilis mutants by expressing lmrB encoding a putative multidrug efflux protein. Eighteen of the mutants altered at two regions (−3 to −1 and +15) immediately downstream of the −10 region of the lmr promoter increased lmr transcription in vivo and in vit...

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Bibliographic Details
Main Authors: Kumano, Miyuki, Fujita, Masaya, Nakamura, Kouji, Murata, Makiko, Ohki, Reiko, Yamane, Kunio
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC148993/
https://ncbi.nlm.nih.gov/pubmed/12499232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.432-435.2003
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