Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication

One hallmark of AIDS progression is a decline in CD4(+) T lymphocytes, though the mechanism is poorly defined. There is ample evidence that increased apoptosis is responsible for some, if not all, of the decline. Prior studies have shown that binding of cellular calmodulin to the envelope glycoprote...

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Hlavní autoři: Micoli, Keith J., Mamaeva, Olga, Piller, Sabine C., Barker, Jennifer L., Pan, George, Hunter, Eric, McDonald, Jay M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489811/
https://ncbi.nlm.nih.gov/pubmed/16229872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2005.08.033
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