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A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G(2) Arrest

The myc family of oncogenes is well conserved throughout evolution. Here we present the characterization of a domain conserved in c-, N-, and L-Myc from fish to humans, N-Myc317-337, designated Myc box IV (MBIV). A deletion of this domain leads to a defect in Myc-induced apoptosis and in some transf...

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Bibliografiske detaljer
Main Authors: Cowling, Victoria H., Chandriani, Sanjay, Whitfield, Michael L., Cole, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489101/
https://ncbi.nlm.nih.gov/pubmed/16705173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01959-05
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