Tethering KSRP, a Decay-Promoting AU-Rich Element-Binding Protein, to mRNAs Elicits mRNA Decay

Inherently unstable mRNAs contain AU-rich elements (AREs) in their 3′ untranslated regions that act as mRNA stability determinants by interacting with ARE-binding proteins (ARE-BPs). We have destabilized two mRNAs by fusing sequence-specific RNA-binding proteins to KSRP, a decay-promoting ARE-BP, in...

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Bibliographic Details
Main Authors: Chou, Chu-Fang, Mulky, Alok, Maitra, Sushmit, Lin, Wei-Jye, Gherzi, Roberto, Kappes, John, Chen, Ching-Yi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489004/
https://ncbi.nlm.nih.gov/pubmed/16648466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.10.3695-3706.2006
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