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Effects of Random Mutations in the Human Immunodeficiency Virus Type 1 Transcriptional Promoter on Viral Fitness in Different Host Cell Environments

A mutation's effect on fitness or phenotype may in part depend on the interaction of the mutation with the environment. The resulting phenotype or fitness is important, since it determines the adaptive potential of a species. To date, most studies have focused on alterations to protein-coding r...

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Autori principali: van Opijnen, Tim, Boerlijst, Maarten C., Berkhout, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488947/
https://ncbi.nlm.nih.gov/pubmed/16775355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02547-05
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