Mutant Escherichia coli Heat-Labile Toxin B Subunit That Separates Toxoid-Mediated Signaling and Immunomodulatory Action from Trafficking and Delivery Functions

The homopentameric B-subunit components of Escherichia coli heat-labile enterotoxin (EtxB) and cholera toxin (CtxB) possess the capacity to enter mammalian cells and to activate cell-signaling events in leukocytes that modulate immune cell function. Both properties have been attributed to the abilit...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Fraser, Sylvia A., de Haan, Lolke, Hearn, Arron R., Bone, Heather K., Salmond, Robert J., Rivett, A. Jennifer, Williams, Neil A., Hirst, Timothy R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Microbial Immunity and Vaccines
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12595472/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.3.1527-1537.2003
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