A search for base analogs to enhance third-strand binding to 'inverted' target base pairs of triplexes in the pyrimidine/parallel motif.

Eight base analogs were tested as third strand residues in otherwise homopyrimidine strands opposite each of the 'direct' (A.T and G.C) and 'inverted' (T.A and C.G) Watson-Crick base pairs, using UV melting profiles to assess triplex stability. The target duplexes contained 20 A.T base pairs and a c...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Amosova, O A, Fresco, J R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1999
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148752/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10556320/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.23.4632
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