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Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.

The human immunodeficiency virus type-1 Rev protein induces the nuclear export of intron-containing viral mRNAs that harbor its binding site, the Rev response element (RRE). A leucine-rich region of Rev, the activation domain, is essential for function and has been shown to be a nuclear export signa...

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Detalhes bibliográficos
Main Authors: Fischer, U, Pollard, V W, Lührmann, R, Teufel, M, Michael, M W, Dreyfuss, G, Malim, M H
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148685/
https://ncbi.nlm.nih.gov/pubmed/10518602
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