Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

Mutations in the WRN gene result in Werner syndrome, an autosomal recessive disease in which many characteristics of aging are accelerated. A probable role in some aspect of DNA metabolism is suggested by the primary sequence of the WRN gene product. A recombinant His-tagged WRN protein (WRNp) was o...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Orren, D K, Brosh, R M, Nehlin, J O, Machwe, A, Gray, M D, Bohr, V A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1999
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148601/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10446247/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.17.3557
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