Structural properties of DNA:RNA duplexes containing 2'-O-methyl and 2'-S-methyl substitutions: a molecular dynamics investigation.

The physical properties of a DNA:RNA hybrid sequence d(CCAACGTTGG)*(CCAACGUUGG) with modifications at the C2'-positions of the DNA strand by 2'-O-methyl (OMe) and 2'-S-methyl (SMe) groups are studied using computational techniques. Molecular dynamics simu-lations of SMe_DNA:RNA, OMe_DNA:RNA and stan...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Venkateswarlu, D, Lind, K E, Mohan, V, Manoharan, M, Ferguson, D M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1999
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10219092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.10.2189
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