Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro.

In this study, we report that eukaryotic topoisomerase I (top1) can linearize the open circular DNA of duck hepatitis B virus (DHBV). Using synthetic oligonucleotides mimicking the three-strand flap DR1 region of the DHBV genome, we found that top1 cleaves the DNA plus strand in a suicidal manner, w...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Pourquier, P, Jensen, A D, Gong, S S, Pommier, Y, Rogler, C E
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 1999
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148402/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10101202/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.8.1919
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