Human DNA topoisomerase I-mediated cleavage and recombination of duck hepatitis B virus DNA in vitro.

In this study, we report that eukaryotic topoisomerase I (top1) can linearize the open circular DNA of duck hepatitis B virus (DHBV). Using synthetic oligonucleotides mimicking the three-strand flap DR1 region of the DHBV genome, we found that top1 cleaves the DNA plus strand in a suicidal manner, w...

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Bibliografiske detaljer
Main Authors: Pourquier, P, Jensen, A D, Gong, S S, Pommier, Y, Rogler, C E
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC148402/
https://ncbi.nlm.nih.gov/pubmed/10101202
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