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Reactivity of potassium permanganate and tetraethylammonium chloride with mismatched bases and a simple mutation detection protocol.

Many mutation detection techniques rely upon recognition of mismatched base pairs in DNA hetero-duplexes. Potassium permanganate in combination with tetraethylammonium chloride (TEAC) is capable of chemically modifying mismatched thymidine residues. The DNA strand can then be cleaved at that point b...

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書誌詳細
主要な著者: Lambrinakos, A, Humphrey, K E, Babon, J J, Ellis, T P, Cotton, R G
フォーマット: Artigo
言語:Inglês
出版事項: 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC148395/
https://ncbi.nlm.nih.gov/pubmed/10101195
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