Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1), the etiologic agent for adult T-cell leukemia (ATL), induces cytokine-independent proliferation of T-cells, associated with the acquisition of constitutive activation of Janus kinases (Jak) and signal transducers and activators of transcriptio...

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Detalhes bibliográficos
Main Authors: Tomita, Mariko, Kawakami, Hirochika, Uchihara, Jun-nosuke, Okudaira, Taeko, Masuda, Masato, Matsuda, Takehiro, Tanaka, Yuetsu, Ohshiro, Kazuiku, Mori, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483830/
https://ncbi.nlm.nih.gov/pubmed/16603085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-3-22
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