Suppression of canonical Wnt/β-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is a genetic disease caused by mutations in desmosomal proteins. The phenotypic hallmark of ARVC is fibroadipocytic replacement of cardiac myocytes, which is a unique phenotype with a yet-to-be-defined molecular mechanism. We establish...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Garcia-Gras, Eduardo, Lombardi, Raffaella, Giocondo, Michael J., Willerson, James T., Schneider, Michael D., Khoury, Dirar S., Marian, Ali J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2006
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483165/
https://ncbi.nlm.nih.gov/pubmed/16823493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27751
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