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Cooperative Fluctuations Point to the Dimerization Interface of P53 Core Domain
Elastic network models are used for investigation of the p53 core domain functional dynamics. Global modes of motion indicate high positive correlations for residue fluctuations across the A-B interface, which are not observed at the B-C interface. Major hinge formation is observed at the A-B interf...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Biophysical Society
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1483080/ https://ncbi.nlm.nih.gov/pubmed/16807229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.077800 |
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