Effect of base analog substitutions in the specific GATC site on binding and methylation of oligonucleotide duplexes by the bacteriophage T4 Dam DNA-[N6-adenine] methyltransferase.

The interaction of the phage T4 Dam DNA-[N6-adenine] methyltransferase with 24mer synthetic oligonucleotide duplexes having different purine base substitutions in the palindromic recognition sequence, GATC, was investigated by means of gel shift and methyl transfer assays. The substitutions were int...

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Detalhes bibliográficos
Main Authors: Malygin, E G, Zinoviev, V V, Petrov, N A, Evdokimov, A A, Jen-Jacobson, L, Kossykh, V G, Hattman, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148295/
https://ncbi.nlm.nih.gov/pubmed/9927748
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