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Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.

In order to identify the basis for the relaxed enantio-selectivity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and to evaluate possible cross-resistance patterns between L-nucleoside-, D-nucleoside- and non-nucleoside RT inhibitors, to be utilised in anti-HIV-1 combinat...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Maga, G, Amacker, M, Hübscher, U, Gosselin, G, Imbach, J L, Mathé, C, Faraj, A, Sommadossi, J P, Spadari, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1999
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148275/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9927728/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.4.972
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