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Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity

The activation of NKG2D on innate and adaptive cytotoxic lymphocytes contributes to immune-mediated tumor destruction. Nonetheless, tumor cell shedding of NKG2D ligands, such as MHC class I chain-related protein A (MICA), results in immune suppression through down-regulation of NKG2D surface express...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Jinushi, Masahisa, Hodi, F. Stephen, Dranoff, Glenn
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482588/
https://ncbi.nlm.nih.gov/pubmed/16754847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603503103
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