Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology

This study describes a method of gene delivery to pancreatic islets of adult, living animals by ultrasound targeted microbubble destruction (UTMD). The technique involves incorporation of plasmids into the phospholipid shell of gas-filled microbubbles, which are then infused into rats and destroyed...

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Main Authors: Chen, Shuyuan, Ding, Jia-huan, Bekeredjian, Raffi, Yang, Bing-zhi, Shohet, Ralph V., Johnston, Stephen A., Hohmeier, Hans E., Newgard, Christopher B., Grayburn, Paul A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482516/
https://ncbi.nlm.nih.gov/pubmed/16709667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602921103
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