Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms

Alternative splicing of pre-mRNA generates two or more protein isoforms from a single gene, thereby contributing to protein diversity. Despite intensive efforts, an understanding of the protein structure–function implications of alternative splicing is still lacking. Intrinsic disorder, which is a l...

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Autors principals: Romero, Pedro R., Zaidi, Saima, Fang, Ya Yin, Uversky, Vladimir N., Radivojac, Predrag, Oldfield, Christopher J., Cortese, Marc S., Sickmeier, Megan, LeGall, Tanguy, Obradovic, Zoran, Dunker, A. Keith
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482503/
https://ncbi.nlm.nih.gov/pubmed/16717195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507916103
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