A conserved bulged adenosine in a peripheral duplex of the antigenomic HDV self-cleaving RNA reduceskinetic trapping of inactive conformations.

In the ribozyme of hepatitis delta virus antigenomic RNA, two short duplexes, P2 and P2a, stabilize the active self-cleaving structure. However, P2a also promotes kinetic trapping of non-native structures. A bulged adenosine (A14) separates P2a and P2; this bulged A is conserved in clinical isolates...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Perrotta, A T, Nikiforova, O, Been, M D
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 1999
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148249/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9889275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.3.795
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