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Mass Defect Labeling of Cysteine for Improving Peptide Assignment in Shotgun Proteomic Analyses

A method for improving the identification of peptides in a shotgun proteome analysis using accurate mass measurement has been developed. The improvement is based upon the derivatization of cysteine residues with a novel reagent, 2,4-dibromo-(2′-iodo)acetanilide. The derivitization changes the mass d...

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Библиографические подробности
Главные авторы: Hernandez, Hilda, Niehauser, Sarah, Boltz, Stacey A., Gawandi, Vijay, Phillips, Robert S., Amster, I. Jonathan
Формат: Artigo
Язык:Inglês
Опубликовано: 2006
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482400/
https://ncbi.nlm.nih.gov/pubmed/16689545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac0600407
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