Mass Defect Labeling of Cysteine for Improving Peptide Assignment in Shotgun Proteomic Analyses

A method for improving the identification of peptides in a shotgun proteome analysis using accurate mass measurement has been developed. The improvement is based upon the derivatization of cysteine residues with a novel reagent, 2,4-dibromo-(2′-iodo)acetanilide. The derivitization changes the mass d...

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Bibliographic Details
Main Authors:	Hernandez, Hilda, Niehauser, Sarah, Boltz, Stacey A., Gawandi, Vijay, Phillips, Robert S., Amster, I. Jonathan
Format:	Artigo
Language:	Inglês
Published:	2006
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1482400/ https://ncbi.nlm.nih.gov/pubmed/16689545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac0600407
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Mass Defect Labeling of Cysteine for Improving Peptide Assignment in Shotgun Proteomic Analyses

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