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Nonviral Aβ DNA vaccine therapy against Alzheimer’s disease: Long-term effects and safety

It was recently demonstrated that amyloid β (Aβ) peptide vaccination was effective in reducing the Aβ burden in Alzheimer model mice. However, the clinical trial was halted because of the development of meningoencephalitis in some patients. To overcome this problem, anti-Aβ antibody therapy and othe...

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Bibliografiske detaljer
Main Authors: Okura, Yoshio, Miyakoshi, Akira, Kohyama, Kuniko, Park, Il-Kwon, Staufenbiel, Matthias, Matsumoto, Yoh
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480456/
https://ncbi.nlm.nih.gov/pubmed/16769900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600966103
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