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Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm

This study compares the relative effects of advancing male age on multiple genomic defects in human sperm [DNA fragmentation index (DFI), chromatin integrity, gene mutations, and numerical chromosomal abnormalities], characterizes the relationships among these defects and with semen quality, and est...

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Detalhes bibliográficos
Main Authors: Wyrobek, A. J., Eskenazi, B., Young, S., Arnheim, N., Tiemann-Boege, I., Jabs, E. W., Glaser, R. L., Pearson, F. S., Evenson, D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480453/
https://ncbi.nlm.nih.gov/pubmed/16766665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506468103
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