Replacement of the positively charged Walker A lysine residue with a hydrophobic leucine residue and conformational alterations caused by this mutation in MRP1 impair ATP binding and hydrolysis

Antzeko izenburuak

• Interaction between the Bound Mg•ATP and the Walker A Serine Residue in NBD2 of Multidrug Resistance-Associated Protein MRP1 Plays a Crucial Role for the ATP-Dependent Leukotriene C4 Transport()
  nork: Yang, Runying, et al.
  Argitaratua: (2008)
• The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis
  nork: Cunningham, Christian N, et al.
  Argitaratua: (2012)
• Glutamine residues in Q-loops of multidrug resistance protein MRP1 contribute to ATP binding via interaction with metal cofactor
  nork: Yang, Runying, et al.
  Argitaratua: (2011)
• Extensive conformational transitions are required to turn on ATP hydrolysis in myosin
  nork: Yang, Yang, et al.
  Argitaratua: (2008)
• ATP hydrolysis is required to reset the ATP-binding cassette dimer into the resting-state conformation
  nork: Lu, Gang, et al.
  Argitaratua: (2005)