Elimination of 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation

The most commonly occurring sialic acid Neu5Ac (N-acetylneuraminic acid) and its deaminated form, KDN (2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid), participate in many biological functions. The human Neu5Ac-9-P (Neu5Ac 9-phosphate) synthase has the unique ability to catalyse the synthesis o...

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Hauptverfasser: Hao, Jijun, Vann, Willie F., Hinderlich, Stephan, Sundaramoorthy, Munirathinam
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479744/
https://ncbi.nlm.nih.gov/pubmed/16503877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20052034
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