Evidence that MutY is a monofunctional glycosylase capable of forming a covalent Schiff base intermediate with substrate DNA.

The Escherichia coli adenine glycosylase MutY is involved in the repair of 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG):A and G:A mispairs in DNA. DNA strand cleavage via beta-elimination (beta-lyase) activity coupled with MutY's removal of misincorporated adenine bases was sought using both qualitative...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Williams, S D, David, S S
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147954/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9801309/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.22.5123
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