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Analysis of the Loading and Hydroxylation Steps in Lankamycin Biosynthesis in Streptomyces rochei

The biosynthetic gene cluster of lankamycin (LM), a 14-member macrolide antibiotic, is encoded on the 210-kb linear plasmid pSLA2-L in Streptomyces rochei 7434AN4. LM contains a 3-hydroxy-2-butyl group at the C-13 position, which is different from an ethyl group in erythromycin. The following two po...

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Bibliografiske detaljer
Main Authors: Arakawa, Kenji, Kodama, Kazuya, Tatsuno, Satoshi, Ide, Sayoko, Kinashi, Haruyasu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479134/
https://ncbi.nlm.nih.gov/pubmed/16723550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00016-06
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