Effect of Porins and Plasmid-Mediated AmpC β-Lactamases on the Efficacy of β-Lactams in Rat Pneumonia Caused by Klebsiella pneumoniae

The in vivo activities of imipenem, meropenem, and cefepime were studied in a model of rat pneumonia caused by a plasmid-mediated AmpC β-lactamase ACT-1-producing Klebsiella pneumoniae strain (K. pneumoniae strain 12) and a derivative porin-deficient mutant (K. pneumoniae strain 12dp). No difference...

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Bibliographic Details
Main Authors: Padilla, Emma, Alonso, Diana, Doménech-Sánchez, Antonio, Gomez, Cristina, Pérez, José Luis, Albertí, Sebastián, Borrell, Nuria
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479113/
https://ncbi.nlm.nih.gov/pubmed/16723600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01513-05
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