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The DNA Binding Activity of p53 Displays Reaction-Diffusion Kinetics

The tumor suppressor protein p53 plays a key role in maintaining the genomic stability of mammalian cells and preventing malignant transformation. In this study, we investigated the intracellular diffusion of a p53-GFP fusion protein using confocal fluorescence recovery after photobleaching. We show...

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Detalhes bibliográficos
Main Authors: Hinow, Peter, Rogers, Carl E., Barbieri, Christopher E., Pietenpol, Jennifer A., Kenworthy, Anne K., DiBenedetto, Emmanuele
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479054/
https://ncbi.nlm.nih.gov/pubmed/16603489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.078303
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