Identification and hydropathic characterization of structural features affecting sequence specificity for doxorubicin intercalation into DNA double-stranded polynucleotides.

The computer molecular modeling program HINT (Hydropathic INTeractions), an empirical hydropathic force field function that includes hydrogen bonding, coulombic and hydrophobic terms, was used to study sequence-selective doxorubicin binding/intercalation in the 64 unique CAxy, CGxy, TAxy, TGxy base...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Kellogg, G E, Scarsdale, J N, Fornari, F A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9753742/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.20.4721
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