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Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB

Escherichia coli and other enterobacteria exploit the H(+)-consuming reaction catalysed by glutamate decarboxylase to survive the stomach acidity before reaching the intestine. Here we show that chloride, extremely abundant in gastric secretions, is an allosteric activator producing a 10-fold increa...

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Hlavní autoři: Gut, Heinz, Pennacchietti, Eugenia, John, Robert A, Bossa, Francesco, Capitani, Guido, De Biase, Daniela, Grütter, Markus G
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1478166/
https://ncbi.nlm.nih.gov/pubmed/16675957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601107
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