XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.

DNA-dependent protein kinase (DNA-PK) plays an important role in DNA double-strand break (DSB) repair and V(D)J recombination. We have isolated a new X-ray-sensitive CHO cell line, XR-C1, which is impaired in DSB repair and which was assigned to complementation group 7, the group that is defective i...

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Dettagli Bibliografici
Autori principali: Errami, A, He, D M, Friedl, A A, Overkamp, W J, Morolli, B, Hendrickson, E A, Eckardt-Schupp, F, Oshimura, M, Lohman, P H, Jackson, S P, Zdzienicka, M Z
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1998
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC147672/
https://ncbi.nlm.nih.gov/pubmed/9628911
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