TAR-RNA binding by HIV-1 Tat protein is selectively inhibited by its L-enantiomer.
An oligoribonucleotide, corresponding to the Tat-interactive top half of the HIV-1 TAR RNA stem-loop, was synthesized in both the natural D- and the enantiomeric L-configurations. The affinity of Tat for the two RNAs, assessed by competition binding experiments, was found to be identical and is redu...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1998
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147661/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611232/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.2886 |
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