The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase.

A common target for therapies against human immuno-deficiency virus type 1 (HIV-1) is the viral reverse transcriptase (RT). Treatment with the widely used nucleoside analog (-)-2', 3'-deoxy-3'-thiacytidine (3TC) leads to the development of resistance-conferring mutations at residue M184 within the Y...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Rezende, L F, Drosopoulos, W C, Prasad, V R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147634/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9611256/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.12.3066
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