Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma

Interleukin-12 (IL-12) enhances Th1-type T-cell responses and exerts antiangiogenic effects. We initiated a phase 1 pilot study of IL-12 in 32 patients with acquired immunodeficiency syndrome (AIDS)–related Kaposi sarcoma (KS) whose KS was progressing while on antiretroviral therapy. Fifteen patient...

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Hlavní autoři: Little, Richard F., Pluda, James M., Wyvill, Kathleen M., Rodriguez-Chavez, Isaac R., Tosato, Giovanna, Catanzaro, Andrew T., Steinberg, Seth M., Yarchoan, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society of Hematology 2006
Témata:
Clinical Trials and Observations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1475826/
https://ncbi.nlm.nih.gov/pubmed/16507779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-11-4455
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