The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates.

A modified phosphoramidite method has been designed for the solid-phase synthesis of two dodecathymidine phosphotriesters and two dodecathymidine thionophosphotriesters. In these analogs, each internucleoside link bears an S -acyl-2-thioethyl (Me-SATE or tBu-SATE) group removable upon esterase activ...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Tosquellas, G, Alvarez, K, Dell'Aquila, C, Morvan, F, Vasseur, J J, Imbach, J L, Rayner, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9547261/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.9.2069
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