Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus.

Antisense oligonucleotides complementary to specific mRNA sequences are widely used inhibitors of gene expression in vitro and in vivo . In vitro cationic lipids have been demonstrated to increase the pharmacological activity of antisense oligonucleotides by increasing cellular uptake and facilitati...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Marcusson, E G, Bhat, B, Manoharan, M, Bennett, C F, Dean, N M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147486/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9518498/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.8.2016
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