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Heat shock protein 60 enhances CD4(+) CD25(+) regulatory T cell function via innate TLR2 signaling

CD4(+)CD25(+) Tregs regulate immunity, but little is known about their own regulation. We now report that the human 60-kDa heat shock protein (HSP60) acts as a costimulator of human Tregs, both CD4(+)CD25(int) and CD4(+)CD25(hi). Treatment of Tregs with HSP60, or its peptide p277, before anti-CD3 ac...

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Detalhes bibliográficos
Main Authors: Zanin-Zhorov, Alexandra, Cahalon, Liora, Tal, Guy, Margalit, Raanan, Lider, Ofer, Cohen, Irun R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474819/
https://ncbi.nlm.nih.gov/pubmed/16767222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28423
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