Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice

Cholangiocellular carcinoma (CC), the second most common primary liver cancer, is associated with a poor prognosis. It has been shown that CCs harbor alterations of a number of tumor-suppressor genes and oncogenes, yet key regulators for tumorigenesis remain unknown. Here we have generated a mouse m...

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Detalhes bibliográficos
Main Authors: Xu, Xiaoling, Kobayashi, Shogo, Qiao, Wenhui, Li, Cuiling, Xiao, Cuiying, Radaeva, Svetlana, Stiles, Bangyan, Wang, Rui-Hong, Ohara, Nobuya, Yoshino, Tadashi, LeRoith, Derek, Torbenson, Michael S., Gores, Gregory J., Wu, Hong, Gao, Bin, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474816/
https://ncbi.nlm.nih.gov/pubmed/16767220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27282
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