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Disruption of the A-Kinase Anchoring Domain in Flagellar Radial Spoke Protein 3 Results in Unregulated Axonemal cAMP-dependent Protein Kinase Activity and Abnormal Flagellar Motility

Biochemical studies of Chlamydomonas flagellar axonemes revealed that radial spoke protein (RSP) 3 is an A-kinase anchoring protein (AKAP). To determine the physiological role of PKA anchoring in the axoneme, an RSP3 mutant, pf14, was transformed with an RSP3 gene containing a mutation in the PKA-bi...

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Autori principali: Gaillard, Anne R., Fox, Laura A., Rhea, Jeanne M., Craige, Branch, Sale, Winfield S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474798/
https://ncbi.nlm.nih.gov/pubmed/16571668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-02-0095
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