Effects of chronic topical application of 12-O-tetradecanoylphorbol-13-acetate on the skin and internal organs of SENCAR mice.

Repetitive topical applications of 2 micrograms 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly for 37 to 52 weeks induced a sustained epidermal hyperplasia, hyperplasia of hair follicles, and increased dermal cellularity in SENCAR mice. In addition, after 52 weeks of protracted promoter tre...

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Main Authors: Klein-Szanto, A J, Conti, C J, Aldaz, C M, Clapp, N, Nesnow, S, Slaga, T J
Formato: Artigo
Idioma:Inglês
Publicado: 1986
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474246/
https://ncbi.nlm.nih.gov/pubmed/3780635
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