Phenylephrine acts via IP(3)-dependent intracellular NO release to stimulate L-type Ca(2+) current in cat atrial myocytes

This study determined the effects of α(1)-adrenergic receptor (α(1)-AR) stimulation by phenylephrine (PE) on L-type Ca(2+) current (I(Ca,L)) in cat atrial myocytes. PE (10 μm) reversibly increased I(Ca,L) (51.3%; n = 40) and shifted peak I(Ca,L) activation voltage by −10 mV. PE-induced stimulation o...

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Detalhes bibliográficos
Main Authors: Wang, YG, Dedkova, EN, Ji, X, Blatter, LA, Lipsius, SL
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2005
Assuntos:
Cell Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474159/
https://ncbi.nlm.nih.gov/pubmed/15946966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.090035
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