Quantification of Homozygosity in Consanguineous Individuals with Autosomal Recessive Disease

Individuals born of consanguineous union have segments of their genomes that are homozygous as a result of inheriting identical ancestral genomic segments through both parents. One consequence of this is an increased incidence of recessive disease within these sibships. Theoretical calculations pred...

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Hlavní autoři: Woods, C. Geoffrey, Cox, James, Springell, Kelly, Hampshire, Daniel J., Mohamed, Moin D., McKibbin, Martin, Stern, Rowena, Raymond, F. Lucy, Sandford, Richard, Malik Sharif, Saghira, Karbani, Gulshan, Ahmed, Mustaq, Bond, Jacquelyn, Clayton, David, Inglehearn, Chris F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society of Human Genetics 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474039/
https://ncbi.nlm.nih.gov/pubmed/16642444
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