Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure

The loss of TGFβ or its downstream mediator, Smad3, key players in tissue repair, accelerates closure of incisional wounds in mice. In contrast, we now report that excisional ear wounds in mice lacking Smad3 enlarge compared with wild-type controls resulting from changes in extracellular matrix mole...

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Bibliografski detalji
Glavni autori: Arany, Praveen R., Flanders, Kathleen C., Kobayashi, Tetsu, Kuo, Catherine K., Stuelten, Christina, Desai, Kartiki V., Tuan, Rocky, Rennard, Stephen I., Roberts, Anita B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Physical Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474013/
https://ncbi.nlm.nih.gov/pubmed/16754864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602473103
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