Crystal structure of the SOCS2–elongin C–elongin B complex defines a prototypical SOCS box ubiquitin ligase

Growth hormone (GH) signaling is tightly controlled by ubiquitination of GH receptors, phosphorylation levels, and accessibility of binding sites for downstream signaling partners. Members of the suppressors of cytokine signaling (SOCS) family function as key regulators at all levels of this pathway...

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Hlavní autoři: Bullock, Alex N., Debreczeni, Judit É., Edwards, Aled M., Sundström, Michael, Knapp, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472497/
https://ncbi.nlm.nih.gov/pubmed/16675548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601638103
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