Clarithromycin Delays Progression of Bronchial Epithelial Cells from G(1) Phase to S Phase and Delays Cell Growth via Extracellular Signal-Regulated Protein Kinase Suppression

The nonsteroidal anti-inflammatory drugs have been shown to support cytoprotection of cells by shifting cells toward a quiescent state (G(0)/G(1)). Extracellular signal-regulated kinase (ERK) is required for cells to pass from G(1) phase into S phase, and macrolide antibiotics can inhibit ERK1/2 pho...

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Main Authors: Shinkai, Masaharu, Tamaoki, Jun, Kobayashi, Hideo, Kanoh, Soichiro, Motoyoshi, Kazuo, Kute, Tim, Rubin, Bruce K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472217/
https://ncbi.nlm.nih.gov/pubmed/16641444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.5.1738-1744.2006
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