Group B Coxsackievirus Diabetogenic Phenotype Correlates with Replication Efficiency

Group B coxsackieviruses can initiate rapid onset type 1 diabetes (T1D) in old nonobese diabetic (NOD) mice. Inoculating high doses of poorly pathogenic CVB3/GA per mouse initiated rapid onset T1D. Viral protein was detectable in islets shortly after inoculation in association with beta cells as wel...

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Bibliographic Details
Main Authors: Kanno, Toru, Kim, Kisoon, Kono, Ken, Drescher, Kristen M., Chapman, Nora M., Tracy, Steven
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472143/
https://ncbi.nlm.nih.gov/pubmed/16699045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02361-05
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