The E7 Oncoprotein Is Translated from Spliced E6*I Transcripts in High-Risk Human Papillomavirus Type 16- or Type 18-Positive Cervical Cancer Cell Lines via Translation Reinitiation

High-risk human papillomaviruses (HPVs) encode two viral oncoproteins, E6 and E7, from a single bicistronic pre-mRNA containing three exons and two introns. Retention of intron 1 in the E6 coding region is essential for production of the full-length E6 oncoprotein. However, splicing of intron 1 is e...

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Bibliographische Detailangaben
Hauptverfasser: Tang, Shuang, Tao, Mingfang, McCoy, J. Philip, Zheng, Zhi-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472016/
https://ncbi.nlm.nih.gov/pubmed/16611884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.9.4249-4263.2006
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